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首先合成顺丁烯二酸酐改性的β-环糊精,垂直沉积制备聚苯乙烯光子晶体模板。然后将改性环糊精与丙烯酸、过硫酸铵、N,N’-亚甲基双丙烯酰胺、诺氟沙星等混合的前驱液填入光子晶体模板中,引发交联聚合,得到蛋白石结构的凝胶光子晶体。再在二甲苯中超声除去聚苯乙烯光子晶体模板,用十二烷基硫酸钠的V(醋酸)∶V(甲醇)=1∶9溶液除去分子印迹模板诺氟沙星,蒸馏水清洗后得到反蛋白石结构的分子印迹凝胶光子晶体。通过对比印迹凝胶光子晶体与非印迹凝胶光子晶体在同样条件下对诺氟沙星的响应性,发现印迹凝胶光子晶体能选择性地迅速响应溶液中的诺氟沙星,当诺氟沙星浓度从10~(-9)mol/L递增到10~(-4)mol/L时,其光子晶体的衍射峰位置从633 nm逐渐红移到722 nm,而非印迹凝胶光子晶体响应性很差。
Firstly, maleic anhydride-modified β-cyclodextrin was synthesized and vertically deposited to prepare a polystyrene photonic crystal template. Then, the modified cyclodextrin is mixed with acrylic acid, ammonium persulfate, N, N’-methylenebisacrylamide, norfloxacin and other precursor liquid into the photonic crystal template to initiate cross-linking polymerization to obtain an opal structure Gel photonic crystal. The polystyrene photonic crystal template was then ultrasonically removed in xylene and the molecularly imprinted template norfloxacin was removed with a solution of sodium dodecyl sulfate in V (acetic acid): V (methanol) = 1: 9. After washing with distilled water, Molecularly imprinted gel photonic crystals with opal structure. By comparing the responsiveness of imprinted gel photonic crystals with non-imprinted gel photonic crystals to norfloxacin under the same conditions, it was found that the imprinted gel photonic crystals can selectively respond rapidly to norfloxacin in solution, When the concentration of the sand star increased from 10 -9 mol / L to 10 -4 mol / L, the photodiffraction of photonic crystal gradually red-shifted from 633 nm to 722 nm, whereas the non-imprinted gel photonic crystal Poor responsiveness.