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目的 探讨异基因外周血干细胞加骨髓移植的临床疗效与急性移植物抗宿主病（ａＧＶＨＤ）发生情况。方法 对ＡＭＬＬ患者以其妹冻存外周血干细胞和骨髓联合移植，并观察疗效和并发症发生情况。结果 患者造血恢复良好，患者移植后为（＋）１９天中性粒细胞数＞０．５×１０~９／Ｌ，＋３０天Ｐｌｔ数＞５０×１０~９／Ｌ。无ａＧＶＨＤ情况。结论 冻存外周血干细胞加骨髓移植是白血病有效的治疗方法，值得进一步探索。
Objective To investigate the clinical efficacy of allogeneic peripheral blood stem cells plus bone marrow transplantation and the incidence of acute graft-versus-host disease (aGVHD). Methods AMLL patients with their sister frozen peripheral blood stem cells and bone marrow transplantation, and observe the efficacy and complications. Results The hematopoietic recovery of patients was good. The number of neutrophils (> 19 days) was> 0.5 × 10 ~ 9 / L after transplantation and the number of Plt> 50 × 10 ~ 9 / L at 30 days after transplantation. No aGVHD condition. Conclusion Cryopreserved peripheral blood stem cells plus bone marrow transplantation is an effective treatment for leukemia, which is worth further exploration.