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目的：观察格列本脲、阿司匹林及小檗碱联合治疗非胰岛素依赖型糖尿病（ＮＩＤＤＭ）的疗效。方法：ＮＩＤＤＭ病人２１８例，男性９８例，女性１２０例，年龄４６±ｓ１１ａ（３２～６５ａ），随机分为联合治疗组８８例，格列本脲组６０例，阿司匹林组３８例，小檗碱组３２例。联合治疗组口服格列本脲２．５～１０ｍｇ，ｂｉｄ，阿司匹林０．３ｇ，ｔｉｄ，小檗碱０．３ｇ，ｔｉｄ；格列本脲组、阿司匹林组及小檗碱组分别单独口服格列本脲、阿司匹林及小檗碱，开始剂量同联合治疗组，再按血糖水平调整。治疗１０ｍｏ。结果：联合治疗组格列本脲用量小于格列本脲组，低血糖反应发生率少；格列本脲组血糖下降，但波动幅度大。阿司匹林及小檗碱组血糖下降缓慢。结论：格列本脲合用阿司匹林及小檗碱治疗ＮＩＤＤＭ疗效较单独用为佳。
Objective: To observe the curative effect of glibenclamide, aspirin and berberine in the treatment of non-insulin-dependent diabetes mellitus (NIDDM). Methods: 218 cases of NIDDM patients, 98 males and 120 females, aged 46 ± s11a (32 ~ 65a) were randomly divided into a combined treatment group of 88 cases, glyburide group of 60 cases, aspirin group of 38 cases, berberine Group of 32 cases. The combined treatment group oral glyburide 2.5 ~ 10mg, bid, aspirin 0.3g, tid, berberine 0.3g, tid; glibenclamide group, aspirin group and berberine group, respectively, The urea, aspirin and berberine, the beginning dose with the combined treatment group, and then adjusted by blood glucose levels. Treatment 10mo. Results: Compared with glibenclamide group, the dosage of glibenclamide in combination therapy group was less than that in glibenclamide group. The glycemic response was lower in glibenclamide group, but the fluctuation range was larger. Aspirin and berberine group blood glucose decreased slowly. Conclusion: Glibenclamide combined with aspirin and berberine in the treatment of NIDDM better than alone.