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[目的]观察疏肝活血方联合阿德福韦酯治疗HBeAg阳性慢性乙型肝炎疗效。[方法]使用随机平行对照方法,将92例住院患者按就诊顺序编号分为两组。对照组46例阿德福韦酯,10mg/次,1次/d,口服。治疗组46例疏肝活血方(茵陈、郁金各4g,泽兰8g,白术6g,白芍10g,茯苓、枳壳各8g,柴胡20g,金钱草8g,赤芍4g),1剂/d,水煎200mL,早晚口服。阿德福韦酯治疗同对照组。连续治疗30d为1疗程。观测临床症状、时间指标、CLDQ评分、不良反应。治疗1疗程,判定疗效。[结果]治疗组痊愈18例,有效24例,无效4例,总有效率91.30%。对照组痊愈14例,有效19例,无效13例,总有效率71.74%。治疗组疗效优于对照组(P<0.05)。时间指标(肝功指标复常时间、HBeAg检测结果完全转阴时间、临床药物治疗方案实施总时间)治疗组少于对照组(P<0.05)。CLDQ评分两组均有改善,治疗组改善优于对照组(P<0.05)。[结论]疏肝活血方联合阿德福韦酯治疗HBeAg阳性慢性乙型肝炎效果显著,值得推广。
[Objective] To observe the curative effect of Shugan Huoxue prescription combined with adefovir dipivoxil on HBeAg-positive chronic hepatitis B patients. [Methods] Using randomized parallel control method, 92 inpatients were divided into two groups according to the order of visiting doctor. Control group, 46 cases of adefovir dipivoxil, 10mg / time, 1 / d, orally. Treatment group, 46 cases of Shugan Huoxue prescription (capillaris, turmeric 4g, Zee 8g, Atractylodes 6g, white peony root 10g, Poria, Citrus aurantium each 8g, Bupleurum 20g, Money grass 8g, red peony 4g), 1 / d, decoction 200mL, morning and evening oral. Adefovir dipivoxil treatment with the control group. Continuous treatment of 30d for a course of treatment. Observed clinical symptoms, time indicators, CLDQ score, adverse reactions. Treatment of a course of treatment to determine the efficacy. [Results] The treatment group cured 18 cases, effective in 24 cases, 4 cases, the total effective rate was 91.30%. In control group, 14 cases were cured, 19 cases were effective, 13 cases were ineffective, and the total effective rate was 71.74%. The treatment group was better than the control group (P <0.05). The time index (normal time of liver function, time of HBeAg test completely negative, total time of clinical drug treatment) was less in the treatment group than in the control group (P <0.05). CLDQ score improved in both groups, the treatment group improved better than the control group (P <0.05). [Conclusion] Shugan Huoxue Decoction combined with adefovir dipivoxil is effective in treating HBeAg-positive chronic hepatitis B, which is worth to be popularized.