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对应用去氢鹅胆酸(CACA)和去氢鸟胆酸(UDCA)进行胆石溶解疗法的机制、适应症、方法、副作用及尚存在的问题进行了阐述。机制胆固醇结石的形成与胆汁中胆汁酸、磷脂浓度降低,胆固醇过饱和即成石性胆汁的生成有关。此外,胆固醇结石患者加速胆固醇合成的β-羟-β-甲基戊二酰辅酶A(HMG-CoA)还原酶活性增强,而促使胆固醇转化为胆汁酸的胆固醇7-α-羟化酶的活性降低。胆酸制剂可以抑制HMG-CoA还原酶的活性,使胆固醇的合成及分泌减少,但有人
The mechanisms, indications, methods, side effects and existing problems of gallstone dissolution therapy using dehydro-gentoic acid (CACA) and dehydro-behenic acid (UDCA) are described. Mechanism of the formation of cholesterol stones and bile bile acids, phospholipids decreased, cholesterol supersaturation that is related to the formation of stone bile. In addition, patients with cholesterol gallstone accelerate the cholesterol synthesis of β-hydroxy-β-methylglutaryl-coenzyme A (HMG-CoA) reductase activity, and promote cholesterol into bile acid cholesterol 7-α-hydroxylase activity reduce. Cholic acid preparations can inhibit the activity of HMG-CoA reductase, cholesterol synthesis and secretion decreased, but some people