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目的:优选白金妇安颗粒中挥发油β-环状精包合物制备工艺。方法:以不同时间挥发油的提取量为指标,采用正交试验法对白金妇安颗粒中的当归、川芎、郁金、牡丹皮的挥发油提取工艺进行优选;以倍他环糊精(β-CD)包封挥发油的包封率为指标,采用正交试验法对白金妇安颗粒中的的挥发油包合工艺进行优选。结果:药材当归、川芎、郁金、牡丹皮粉碎成粗粉,加5倍量的水,浸泡2 h,水蒸气蒸馏法提取挥发油5 h。取挥发油5倍量的β-环糊精,加入1倍β-CD量20%乙醇,研磨成糊状,加入挥发油,继续研磨2 h,得糊状物,低温干燥。结论:确定的工艺合理,有效成分提取率高。
Objective: To optimize the preparation process of volatile oil β-cyclodextrin inclusion complex in Platinum Fufang granule. Methods: The volatile oil extraction process of Angelica, Chuanxiong, Tulip and Cortex Moutan was optimized by orthogonal test with orthogonal test. The β-CD ) Encapsulation of volatile oil encapsulation efficiency as an indicator, the orthogonal test method of Platinum Fu-An particles in the volatile oil inclusion process optimization. Results: Radix Angelicae Sinensis, Rhizoma Chuanxiong, Turmeric and Moutan bark were crushed into coarse powder, 5 times the amount of water, soaked for 2 h, and the volatile oil was extracted by steam distillation for 5 h. Take 5 times the amount of β-cyclodextrin essential oil, add 1 times the amount of β-CD 20% ethanol, ground into a paste, add volatile oil and continue grinding 2 h, the paste, low temperature drying. Conclusion: The process is reasonable and the extraction rate of active ingredients is high.