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多发性骨髓瘤病人容易发生感染,在化疗时则更甚,这主要是由于病员有免疫功能的缺陷,以致对于入侵的细菌不能作有效的防卫和杀灭。体液免疫与多发性骨髓瘤的关系主要是正常多克隆免疫球蛋白(PIg)减少。Abdou等~1认为在多发性骨髓瘤(简称MM)时尽管血清Ig增加,但带有PIg的B淋巴细胞明显减少为5±2%,而在正常人则为15±5%或22±7%。绝大多数B淋巴细胞带有个体基因型Ig(Idiotypic Ig),它们是异常的单克隆Ig,而非正常B淋巴细胞上的PIg,这可
Patients with multiple myeloma are prone to infection and even worse during chemotherapy. This is mainly due to the defect of the immune function of the patient so that the invading bacteria can not be effectively defended and killed. Humoral immunity and multiple myeloma is mainly the normal polyclonal immunoglobulin (PIg) reduction. Abdou et al1 considered that while serum Ig was increased in multiple myeloma (MM for short), the percentage of B lymphocytes with PIg was significantly reduced to 5 ± 2% compared to 15 ± 5% or 22 ± 7 in normal individuals %. The vast majority of B lymphocytes carry idiotype Ig, which are aberrant monoclonal Ig rather than PIg on non-normal B lymphocytes