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磷酸羟基哌喹(HPQP)是最近几年合成的一种新抗疟药。经实验研究和临床观察表明该药比其它抗疟药治疗效果甚为显著,而且,还发现该药治疗矽肺等疾病疗效也较好。已证实该药具有使矽肺患者症状减轻和减少细胞损伤的作用。该药用于临床治疗心律紊乱也有疗效,但是用药一段时间后,患者有皮色变黑的症象。为了保证长期用药的安全,亦为了探讨该药的作用机制,我们观察了 HPQP 毒性试验狗血浆皮质醇含量的变化,以了解肾上腺皮质功能的状态。
Hydroxypipequi phosphate (HPQP) is a new antimalarial drug synthesized in recent years. The experimental studies and clinical observations show that the drug is more effective than other anti-malarial drugs, and the drug is also found to be effective in treating silicosis and other diseases. It has been shown that this medicine has the effect of reducing symptoms and reducing cell damage in patients with silicosis. The drug is also used for clinical treatment of cardiac rhythm disorders are also effective, but after a period of medication, patients have skin darkening symptoms. In order to ensure the safety of long-term medication, and to explore the mechanism of action of this drug, we observed the change of plasma cortisol level in HPQP toxicity test dogs to understand the status of adrenocortical function.