环戊基(口派)嗪力复霉素(R77—3)系四川抗菌素工业研究所近年研制成的利福平类的新衍生物。该药经体内外抗菌作用及临床前药理研究,证明它也具有对G~+菌抗菌作用强,口服吸收快,半衰期为14小时,药效时间持久等特点的长效抗生素。我们在试用该药治疗急性肺部感染病人的过程中,同时测定了13例患者口服首剂(0.4克)后2～48小时7次的血药浓 Cyclopentyl (mouth) trimethoprim (R77-3) Department of Sichuan Institute of Antibiotics recently developed a new derivative of rifampicin class. The antibacterial effect of the drug in vitro and in vivo and preclinical pharmacological studies have shown that it also has a strong antibacterial effect on G ~ + bacteria, oral absorption fast, half-life of 14 hours, long-lasting antibacterial properties such as long-acting antibiotics. We tried this drug in the treatment of patients with acute lung infection in the same time, the determination of 13 patients oral administration of the first dose (0.4 g) 2 to 48 hours after 7 times the concentration of blood