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乙酰丹酚酸Ａ（ＡＳＡＡＡＳ）是丹参有效成分的衍生物。用三氯化铁局部涂抹损伤血管形成大鼠大脑中动脉血栓模型。以脑梗塞范围、行为障碍、脑组织病理改变为观察指标，研究ＡＳＡＡ对大脑中动脉血栓所致局部脑缺血的预防作用。结果表明，ＡＳＡＡ５０及１００ｍｇ·ｋｇ￣（１）ｉｖ可显著降低大鼠脑梗塞范围，改善行为障碍。脑组织检查中，ＡＳＡＡ１００ｍｇ·ｋｇ－１组动物大脑中动脉内血栓形成极少或未形成，脑组织缺血病变较轻。以上结果提示，ＡＳＡＡ可能通过抑制脑血栓形成，从而减轻血栓形成所致的局部脑缺血性损伤。
Acetyl salvianolic acid A (ASAAAS) is a derivative of the active ingredient of Salvia miltiorrhiza. Topical application of ferric chloride to impaired vascularization of rat middle cerebral artery occlusion model. To observe the range of cerebral infarction, behavioral disorders, pathological changes of brain tissue to study ASAA on cerebral ischemia caused by middle cerebral artery occlusion. The results showed that ASAA50 and 100mg · kg ~ (1) iv can significantly reduce the range of cerebral infarction in rats and improve behavioral disorders. Brain tissue examination, ASAA100mg · kg-1 group of animals with little or no middle cerebral artery thrombosis, ischemic lesions of brain tissue lighter. These results suggest that ASAA may reduce cerebral thrombosis caused by local cerebral ischemic injury.