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目的：探讨二倍体恶性肿瘤预后的影响因素。方法：用流式细胞术检测了７８ 例二倍体恶性肿瘤患者癌旁组织的 Ｄ Ｎ Ａ 含量和增殖活性。结果：在７８ 例二倍体恶性肿瘤癌旁组织中，有２４４ ％ 出现了 Ｄ Ｎ Ａ 异倍体细胞，其 Ｄ Ｉ 值为（１２４ ±０１９） ；非整倍体占全部异倍体的８４２ ％ ，多异倍体占１５８ ％ ；其 Ｓ期细胞比率明显高于二倍体中心灶（ 分别为２６８ ％ 和１７８ ％ ， Ｐ ＜ ００５） ， 与异倍体中心灶接近（２２０ ％ ） 。结论：二倍体肿瘤患者癌旁组织的 Ｄ Ｎ Ａ 倍体特性和细胞增殖活性可能是影响二倍体肿瘤患者预后的重要因素。
Objective: To explore the influencing factors of the prognosis of diploid malignant tumors. Methods: Flow cytometry was used to detect the D N A content and proliferation activity in paraneoplastic tissue of 78 patients with diploid malignancy. RESULTS: In the adjacent tissues of 78 cases of diploid malignant tumors, 24.4% of D N A aneuploid cells appeared, and their D I values were (1 24 ± 0 19); aneuploidy was accounted for. 84% 2% of all aneuploids accounted for 15.8% of alloploids; the percentage of S phase cells was significantly higher than that of diploid focus (26.8% and 17.8%, respectively; P < 0. 05), close to the center of aneuploidy (22.0%). Conclusion: D N A ploidy characteristics and cell proliferative activity in adjacent tissues of diploid tumors may be important factors influencing the prognosis of patients with diploid tumors.