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目的探讨新疆维吾尔族人群缺血性脑卒中发病风险与相关血液生化指标的关系。方法采用1:1配对的病例对照研究设计,对所选择的研究对象进行调查。结果总蛋白水平、白蛋白水平、血糖水平、高密度脂蛋白水平存在统计学差异。单因素Logistic回归分析,总蛋白(OR=0.85,95%CI:0.80～0.90)、白蛋白(OR=0.79,95%CI:0.73～0.85)及高密度脂蛋白(OR=0.06,95%CI:0.02～0.18)为缺血性脑卒中的保护因素,高血糖(OR=1.35,95%CI:1.14～1.60)为缺血性脑卒中的危险因素;多因素Logistic回归分析表明白蛋白(OR=0.86,95%CI:0.75～0.99)及高密度脂蛋白(OR=0.32,95%CI:0.15～0.64)为独立保护因素。结论高血糖可能增加缺血性脑卒中的发病风险,血液中白蛋白与高密度脂蛋白可能与维吾尔族人群缺血性脑卒中的易感性相关。
Objective To explore the relationship between the risk of ischemic stroke and the related blood biochemical indexes in Xinjiang Uighur population. Methods The case-control study design with 1: 1 pairing was used to investigate the selected subjects. Results The levels of total protein, albumin, blood glucose and high density lipoprotein were statistically different. Logistic regression analysis showed that total protein (OR = 0.85, 95% CI: 0.80-0.90), albumin (OR = 0.79, 95% CI: 0.73-0.85) and high density lipoprotein (OR = 1.35, 95% CI: 1.14-1.60) were risk factors for ischemic stroke. Multivariate logistic regression analysis showed that albumin (OR = 0.86, 95% CI: 0.75 ~ 0.99) and high density lipoprotein (OR = 0.32, 95% CI: 0.15 ~ 0.64) were independent protective factors. Conclusion Hyperglycemia may increase the risk of ischemic stroke. Serum albumin and high density lipoprotein may be related to the susceptibility to ischemic stroke in Uighur population.