论文部分内容阅读
本文以单独使用长效dl-15-甲基PGF_(2α)(给药方式为阴道内放置含药海绵和肌肉注射)48例为对照,与合并使用dl-15-甲基PGF_(2α)加丙酸睾丸酮的139例进行终止早孕的比较研究。研究结果表明:两组的成功率各为93.75%及98.56%(P<0.05),平均引-流时间分别为25小时及13.5小时,PG 的平均用药剂量各为11.58及10.33毫克(P<0.05),蜕膜完整及大块排出各为31.25%及48.20%(P<0.01),两组的阴道流血时间无明显差异。以上结果提示:合并用药组的临床效果较好,且用药剂量小。作者对部分受试者作了肝功能检查、病理切片的光镜、电镜检查和血清HCG 及血浆孕酮的放射免疫测定。认为合并用药之所以取得较好的临床效果,可能是由于丙酸睾丸酮加强了前列腺素的流产效应。
In this paper, 48 cases of long-term use of long-acting dl-15-methyl PGF_ (2α) alone (intraperitoneal drug-containing sponges and intramuscular injection) as a control, combined with the use of dl-15-methyl PGF_ (2α) plus 139 cases of testosterone propionate for termination of early pregnancy comparative study. The results showed that the success rates of the two groups were 93.75% and 98.56% (P <0.05), the average lead time was 25 hours and 13.5 hours, respectively. The mean doses of PG were 11.58 and 10.33 mg (P <0.05) ), Decidua complete and bulk discharge of 31.25% and 48.20% (P <0.01), the two groups of vaginal bleeding time no significant difference. The above results suggest that: the combined effect of the drug group is better, and the dosage is small. The author of some subjects for liver function tests, pathological sections of light microscopy, electron microscopy and serum HCG and plasma progesterone radioimmunoassay. That the reason why the combination of medication to achieve better clinical results, may be due to testosterone propionate to enhance the abortion effect of prostaglandins.