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目的 探讨血浆渗透压测定在临床脑卒中治疗中的价值和意义。方法 对 2 11例脑卒中患者进行了入院血浆渗透压测定 ,其中 35例在第 1周进行了动态监测。结果 住院期间死亡者入院血浆渗透压水平 (30 5 .6 6± 13.4 5mOsm/kg .H2 O)高于存活者 (2 92 .0 1± 9.0 0mOsm/kg·H2 O) ,入院血浆渗透压是影响住院病死率的独立危险因素 (OR =7.75 ,95 %CI 3.2 2～ 16 .90 ) ,其水平与脑卒中类型 (出血或缺血 )无关 ,与病变程度有关。动态监测显示血浆渗透压与甘露醇用量有关。结论 血浆渗透压是评价急性脑卒中预后并指导治疗的可靠指标之一。
Objective To investigate the value and significance of plasma osmolality in the treatment of clinical stroke. Methods Totally 211 inpatients with stroke were enrolled in the study of plasma osmolality, of which 35 were dynamically monitored during the first week. Results The in-hospital plasma osmolality (30.56 ± 13.4 5mOsm / kg · H 2 O) was higher than that of survivors (92.02 ± 0.090mOsm / kg · H 2 O) The independent risk factors affecting hospital mortality (OR = 7.75, 95% CI 3.2 2 ~ 16.90) were independent of stroke type (hemorrhage or ischemia) and were related to the severity of the disease. Dynamic monitoring showed that plasma osmolality was related to the amount of mannitol used. Conclusion Plasma osmotic pressure is one of the reliable indicators to evaluate the prognosis of acute stroke and to guide the treatment.