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本文作者报告了3例卡马西平中毒的病例。病例1:肝炎。女性,49岁。由于情绪高涨,言语增多,睡眠减少,性功能亢进而入院。躯体和实验室检查无异常。用卡马西平治疗,四周后,病人出现恶心、呕吐、厌食。卡马西平剂量每天1200mg,血清浓度105μg/dl,此时体温99.4F,巩膜黄染,右上腹压痛,肝脏在锁骨中线处为10cm。立即停用卡马西平,转内科治疗,实验室检查发现:血清胆红素5.7mg/dl(正常0.1~1.2mg/dl); SGOT(谷草转氨酶)319单位(正常0~40单位);SGPT(谷丙转氨酶)384单位(正常0~53单位);碱性磷酸酶623单位
The authors report three cases of carbamazepine poisoning. Case 1: Hepatitis. Female, 49 years old. Due to rising emotions, speech, decreased sleep, sexual function and admission. Body and laboratory tests were normal. With carbamazepine treatment, four weeks later, the patient nausea, vomiting, anorexia. Carbamazepine daily dose of 1200mg, serum concentration 105μg / dl, when the body temperature of 99.4F, scleral yellow dye, right upper quadrant tenderness, liver in the midline of the clavicle to 10cm. Immediate discontinuation of carbamazepine, medical treatment, laboratory tests found that: serum bilirubin 5.7mg / dl (normal 0.1 ~ 1.2mg / dl); SGOT (aspartate aminotransferase) 319 units (normal 0 to 40 units); SGPT (Alanine aminotransferase) 384 units (normal 0 to 53 units); alkaline phosphatase 623 units