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目的 :探讨小剂量米索前列醇 (以下称米索 )对晚期妊娠促子宫颈成熟的有效性和安全性。方法 :无米索禁忌证、单胎、头位、胎膜未破、孕 38～≥ 42周孕妇 5 6例。随机分为研究组 (A组 ) 2 8例 :以小剂量米索 (2 5 μg)每 4～ 6h放置阴道后穹窿内 ,最大总量为 10 0 μg ;对照组 (B组 ) 2 8例 :以 0 .5 %催产素 5 0 0ml静脉滴注 ,1次 /天 ,共 2次。 结果 :A组总有效率为78.5 7% ;B组总有效率为 6 2 .2 9% ;两组差异无显著性 (P >0 .0 5 )。A组总产程短于B组 ,而两组分娩方式与母婴安全差异均无显著性 (P >0 .0 5 )。结论 :小剂量米索用于晚期妊娠促子宫颈成熟有效而且安全
Objective: To investigate the efficacy and safety of low-dose misoprostol (hereinafter referred to as misoprostol) in promoting cervical ripening in late pregnancy. Methods: No indications of misoprostol, single fetus, head position, unbroken fetal membranes, 56 pregnant women 38 ~ 42 weeks pregnant. Were randomly divided into study group (group A) 28 cases: a small dose of misoprostol (25 μg) every 4 ~ 6 h placed vaginal fornix, the maximum total of 10 0 μg; control group (B) 28 cases : 0 .5% oxytocin 500 ml intravenously, 1 time / day, a total of 2 times. Results: The total effective rate in group A was 78.5 7%. The total effective rate in group B was 62.92%. There was no significant difference between the two groups (P> 0.05). The total length of labor in group A was shorter than that in group B, but there was no significant difference between the two groups in the mode of delivery and the safety of mother and infant (P> 0.05). Conclusion: Small dose of misoprostol is effective and safe for promoting cervical ripening in late pregnancy