论文部分内容阅读
目的探讨自体骨髓单个核细胞移植对终末期肝病的治疗作用及不良反应。方法 22例终末期肝病患者,经骨髓动员后于髂前上嵴穿刺抽取骨髓液分离单个核细胞,采用介入技术经肝动脉植入肝脏中,观察治疗前、后肝脏代谢功能、合成功能、凝血功能和肝损伤指标的改变及不良反应。结果自体骨髓单个核细胞移植后随访24周,与治疗前比较,前白蛋白、白蛋白、胆碱酯酶、总胆红素、直接胆红素、总胆汁酸、凝血酶原时间、纤维蛋白原、丙氨酸氨基转移酶、门冬氨酸氨基转移酶、γ-谷氨酰转肽酶和碱性磷酸酶均无明显改善(P>0.05),治疗过程中无明显不良反应。结论自体骨髓单个核细胞移植对终末期肝病的疗效有限,尚需进一步改进。
Objective To investigate the therapeutic effect and adverse reactions of autologous bone marrow mononuclear cell transplantation on end-stage liver disease. Methods Twenty-two patients with end-stage liver disease undergoing mobilization of the bone marrow isolated mononuclear cells from the bone marrow of the anterior superior iliac spine and were transplanted into the liver via hepatic artery using the interventional technique. The hepatic metabolism, synthesis and coagulation were observed before and after treatment Function and liver injury index changes and adverse reactions. Results After autologous bone marrow mononuclear cells were followed up for 24 weeks, prealbumin, albumin, cholinesterase, total bilirubin, direct bilirubin, total bile acid, prothrombin time, fibrin There was no significant difference between the original, alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transpeptidase and alkaline phosphatase (P> 0.05). There was no obvious adverse reaction during the treatment. Conclusion Autologous bone marrow mononuclear cell transplantation has limited efficacy in the treatment of end-stage liver disease and needs to be further improved.