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急性肝衰竭的治疗重点是刺激肝细胞再生和促进肝功能恢复。胰岛素和胰高糖素是可用于这一目的的治疗药物。胰岛素和胰高糖素治疗肝衰竭的疗效 Farivar等报道胰岛素和胰高糖素对提高暴发性病毒性肝炎鼠存活率有显效,但不能排除该两药物作为激素具有抗病毒攻击的作用。本文作者对体重180～200g雄性Spraque-Dawley大鼠每24小时腹腔内注射二甲基亚硝基胺(DMN)15mg/kg,诱发严重肝损害。在最初24小时后,对这些鼠每4小时皮下注射不同剂量的胰岛素和胰高糖素,当所给剂量达到120mU/kg胰岛素和75μg/kg胰高糖素时,100小时后存活率显著增高,但140小时后效果消失。当胰高糖素剂量降低到上述剂量的十
The treatment of acute liver failure focuses on stimulating hepatocyte regeneration and promoting recovery of liver function. Insulin and glucagon are therapeutic drugs that can be used for this purpose. Efficacy of Insulin and Glucagon in Treating Liver Failure Farivar et al reported that insulin and glucagon are effective in raising the survival rate of fulminant viral hepatitis mice but that these two drugs can not be ruled out as antihormonal attacks as hormones. In this study, male Spraque-Dawley rats weighing 180-200 g were injected intraperitoneally with dimethylnitrosamine (DMN) 15 mg / kg every 24 hours to induce severe liver damage. After the first 24 hours, these mice were injected subcutaneously with different doses of insulin and glucagon every 4 hours, with a significant increase in survival after 100 hours at doses up to 120 mU / kg of insulin and 75 μg / kg of glucagon, But the effect disappeared after 140 hours. When the glucagon dose is reduced to ten above the dose