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本文观察１２例梗阻性黄疸患者在围手术期免疫功能的变化。结果提示，黄疸期患者血清ＴＮＦ和经ＬＰＳ诱生的ＴＮＦａ水平明显高于成年健康对照者，中性粒细胞吞噬和杀菌功能则显著低于对照者，静息淋巴细胞群中ｍＩＬ－２Ｒ＋细胞百分率以及Ｔ和Ｂ淋巴细胞数无多改变。当黄疸消退后第七天，患者血清ＴＮＦ和ＴＮＦａ水平即迅速下降，接近正常水平，中性粒细胞功能随黄疸消失而逐渐增加，至第３０天基本恢复正常，其余指标无明显改变。文中列举典型病例的４项免疫参数的动态变化，提示患者血清ＴＮＦ和ＴＮＦａ水平与中性粒细胞功能呈负相关。
This article observed 12 cases of obstructive jaundice in patients with perioperative immune function changes. The results suggest that the levels of serum TNF and LPS-induced TNFa in patients with jaundice were significantly higher than those in healthy adults, the phagocytosis and bactericidal activity of neutrophils were significantly lower than those in controls, the percentage of mIL-2R + cells in resting lymphocytes As well as T and B lymphocyte number without change. On the seventh day after the jaundice subsided, the levels of serum TNF and TNFa decreased rapidly and approached the normal levels. The function of neutrophils increased gradually with the disappearance of jaundice, and returned to normal on the 30th day with no significant change in other indicators. The dynamic changes of four immune parameters in typical cases are listed in this paper, which indicate that the levels of serum TNF and TNFa are negatively correlated with neutrophil function.