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目的了解0岁~16岁儿童维生素D营养状况及其与年龄、性别、季节的关系,为本地区儿童合理补充维生素D提供科学依据。方法对2012年4月-2014年11月来温州医科大学附属第二医院育英儿童医院保健科体检的0岁~16岁6 651例儿童,采用电化学发光法进行血清25-羟维生素D水平检测。结果 6 651例儿童25-羟维生素D水平为(29.63±12.83)ng/ml,其中25-羟维生素D严重缺乏组92例(1.38%),缺乏组1 498例(22.52%),不足组2 434例(36.60%),充足组2 627例(39.50%)。0~岁组和1~岁组儿童血清25-羟维生素D水平明显高于其他年龄组,差异有统计学意义(P<0.05),3岁后儿童血清25-羟维生素D水平明显下降,各年龄组间差异有统计学意义(P<0.01)。不同性别间血清25-羟维生素D水平差异无统计学意义(t=1.373,P>0.05)。不同季节儿童血清25-羟维生素D水平秋季最高,夏季最低。结论 0岁~16岁儿童25-羟维生素D水平低下,应增加该地区儿童的维生素D摄入量,尤需加强6岁以上儿童维生素D的补充及夏季儿童的户外活动。
Objective To understand the nutritional status of vitamin D in children aged 0-16 and its relationship with age, sex and season so as to provide a scientific basis for rational vitamin D supplementation in children in this area. Methods From April 2012 to November 2014, 6 651 children aged 0-16 years old undergoing physical examinations at Yuying Children’s Hospital, Second Affiliated Hospital of Wenzhou Medical University were enrolled in this study. Serum 25-hydroxyvitamin D levels were detected by electrochemiluminescence . Results The level of 25-hydroxyvitamin D in 6 651 children was (29.63 ± 12.83) ng / ml, of which 92 (1.38%) were severe in 25-hydroxyvitamin D deficiency and 1 498 (22.52% 434 cases (36.60%), adequate group of 2 627 cases (39.50%). Serum levels of 25-hydroxyvitamin D were significantly higher in children aged 0 to 1 years and those in 1-year-old group than those in other age groups (P <0.05). Serum levels of 25-hydroxyvitamin D in children aged 0 ~ The difference between the age groups was statistically significant (P <0.01). There was no significant difference in serum 25-hydroxyvitamin D levels between different genders (t = 1.373, P> 0.05). In different seasons children’s serum 25-hydroxyvitamin D level was highest in autumn and lowest in summer. Conclusion The low level of 25-hydroxyvitamin D in children aged 0-16 years should increase the intake of vitamin D in children in this area, especially the supplement of vitamin D in children over 6 years old and the outdoor activities of children in summer.