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1971年就有报道,在因肠道炎症而接受回肠切除的患者中,肾脏有草酸钙结石形成。用小肠搭桥术治疗肥胖症也出现了同样的现象。研究证明,这些患者的尿中草酸(C_2H_2O_4)排泄量增加,是由大肠吸收草酸增加所致。即由于不能吸收胆汁酸而致胆汁缺乏,从而引起脂肪吸收不良。长链脂肪酸与钙离子结合,使未与钙离子结合的可吸收草酸增加。草酸为被动吸收,大量的草酸吸收后导致尿中排泄量增加。另外,脂肪酸和胆汁酸不被小肠吸收而达大肠,会致大肠对草酸的透过性增加,从而引起“肠性高草酸尿症”。这一理论是1973~1975提
It was reported in 1971 that due to intestinal inflammation in patients undergoing ileal resection, the kidneys have calcium oxalate stones formation. The same phenomenon occurs with the treatment of obesity with small bowel bypass. Studies have shown that these patients urinary oxalic acid (C 2 H 2 O 4) excretion increased by the large intestine to absorb oxalic acid due to increased. That can not absorb bile acids caused by lack of bile, which led to poor fat absorption. Long chain fatty acids combine with calcium ions to increase the absorbable oxalate that is not bound to calcium ions. Oxalic acid is a passive absorption, a large amount of oxalic acid absorption leads to increased urinary excretion. In addition, fatty acids and bile acids are not absorbed by the small intestine and reach the large intestine, will lead to increased permeability of the large intestine to oxalic acid, causing “intestinal hyperoxaluria.” This theory is 1973 ~ 1975 mentioned