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为探讨在非胰岛素依赖型糖尿病（NIDDM）病人检测血清脂蛋白（a）［Lp（a）］的临床意义，研究52例NIDDM病人和30例正常人的Lp（a）、空腹血糖．分析Lp（a）水平与有或无合并症的NIDDM的关系．检测了80例对象为正常人、可疑糖尿病、确诊NIDDM的空腹血糖（FPG），观察不同水平的空腹血糖与相对应的Lp（a）关系。结果显示：①有合并症的MIDDM组，无合并症的NIDDM组和正常对照组Lp（a）水平分别为：750．9±275．7mg／L，530．6±408．4mg／L，189．5±98．6mg／L，有或无并发症的NIDDM病人的Lp（a）水平均较正常对照显著增高P＜0．05．②Lp（a）水平与空腹血糖水平呈正相关（r＝0．29，P＜0．01），并以FPG含量区段分组可见Lp（a）平均含量随FPG平均含量增高而增高．故认为Lp（a）水平在判定NIDDM病人的病情轻重和血糖控制与否是一项有参考价值的指标。
To investigate the clinical significance of detecting serum lipoprotein (a) [Lp (a)] in non-insulin dependent diabetes mellitus (NIDDM), we investigated the Lp (a) and fasting plasma glucose in 52 NIDDM patients and 30 healthy controls. The relationship between Lp (a) level and NIDDM with or without comorbidity was analyzed. Eighty healthy subjects were tested for suspicious diabetes, and fasting plasma glucose (FPG) was measured in patients with NIDDM. The relationship between different levels of fasting blood glucose and the corresponding Lp (a) was observed. The results showed that: ① The Lp (a) levels of MIDDM group, NIDDM group without complications and control group were 750.9 ± 275.7mg / L, 530.6 ± 408.4mg / L, 189 .5 ± 98.6mg / L, with or without complications in patients with NIDDM Lp (a) levels were significantly higher than the normal control P <0.05. (2) There was a positive correlation between Lp (a) level and fasting blood glucose level (r = 0.29, P <0.01), and the average content of Lp (a) increased with the increase of FPG level in the group of FPG. Therefore, the level of Lp (a) in determining the severity of NIDDM patients and glycemic control or not is a reference value index.