Hipocrates 首先用哮喘一词来描述发作性呼吸困难。此后有人认为哮喘是人肺的过敏反应。当抗原与结合在细胞表面的抗体反应时,由致敏细胞释放具有生物活性的化学介质,从而引起过敏反应和变态反应。早期研究认为组织胺可引起类似过敏反应一样的作用,故提出组织胺是过敏反应的介质。实验证明致敏的肺用含抗原的溶液灌流时,其释放的组织胺足以 Hipocrates first used the term asthma to describe episodic dyspnea. Since then, some people think that asthma is an allergic reaction to the human lung. When an antigen reacts with an antibody that binds to the cell surface, the biologically active chemical mediator is released by the sensitized cell, causing an allergic reaction and an allergic reaction. Early studies suggest that histamine can cause similar allergic reactions the same role, it is proposed that histamine is allergic reaction medium. Experiments show that sensitized lungs with antigen-containing solution perfusion, the release of histamine sufficient