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目的:观察缬沙坦联合金水宝胶囊对早期糖尿病肾病患者微炎症状态的影响。方法:80例糖尿病肾病患者分为对照组和观察组,对照组常规给予降糖、调脂、降压及饮食控制等常规治疗,观察组在此基础上,给予缬沙坦联合金水宝胶囊。疗程1个月。观察治疗前后24 h尿蛋白排泄率(UAER)、尿素氮(BUN)、血肌酐(Scr)、C-反应蛋白(CRP)及肿瘤坏死因子(TNF-α)的变化。结果:治疗后观察组CRP及TNF-α指标明显降低,与对照组比较,差异有统计学意义(P<0.05),其他指标两组比较,差异无统计学意义(P>0.05)。结论:缬沙坦联合金水宝胶囊对早期糖尿病肾病患者微炎症状态有一定治疗作用。
Objective: To observe the effect of valsartan combined with Jinshuibao on the microinflammatory state in patients with early diabetic nephropathy. Methods: Eighty patients with diabetic nephropathy were divided into control group and observation group. The control group was given conventional therapy such as hypoglycemic, lipid-lowering, antihypertensive and diet control. The observation group was given valsartan combined with Jinshuibao capsule. Treatment for 1 month. The changes of urinary protein excretion rate (UAER), blood urea nitrogen (BUN), serum creatinine (Scr), C-reactive protein (CRP) and tumor necrosis factor (TNF-α) were observed before and 24 hours after treatment. Results: After treatment, CRP and TNF-α in observation group were significantly lower than those in control group (P <0.05). There was no significant difference in other indexes between the two groups (P> 0.05). Conclusion: Valsartan combined with Jinshuibao capsule can reduce the microinflammatory state of patients with early diabetic nephropathy.