从海南岛采集了桶形芋螺标本１０ｋｇ。比较了“超低温脆化法”，“匀浆法”，“剥离法”的取毒效果。经凝胶过滤色谱分离后，共得粗毒液 ５０４ｍｇ，其中，Ｐ１，２１０ｍｇ，分子量 Ｍｗ＞５０００；Ｐ２，１８４ｍｇ，Ｍｗ＝１０００～５０００；Ｐ３，５０ｍｇ，Ｍｗ＜１０００。用高效液相色谱（ＨＰＬＣ）和高效毛细管电泳（ＨＰＣＥ）对 Ｐ２，Ｐ３进行了比较研究。毒液经 ＨＰＬＣ分离后得到数十个成分，各成分多数在２０ｍｇ以内。药理实验表明，它们具有一系列中枢神经活性（ＣＮＳ）。 A 10kg barrel-type snail specimen was collected from Hainan Island. The effects of “ultra-low temperature embrittlement method”, “homogenization method” and “stripping method” were compared. After gel filtration chromatography, a total of 504 mg of crude venom was obtained, of which, P1, 210 mg, molecular weight Mw>5000; P2,184 mg, Mw=1000-5000; P3, 50 mg, Mw<1000. The P2 and P3 were compared by high performance liquid chromatography (HPLC) and high performance capillary electrophoresis (HPCE). After the venom was separated by HPLC, dozens of components were obtained, and most of the components were within 20 mg. Pharmacological experiments show that they have a series of central nervous activity (CNS).