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在抗病毒治疗期间肝内丙型肝炎病毒(HCV)抗原表达的改变尚未被验证。本文作者评价了慢性丙型肝炎病人在抗病毒治疗前后肝脏HCV抗原表达的存在和意义。 本研究收集了1987～1991年参与抗病毒治疗试验的35例病人的49份肝活检标本。24例接受6或12个月的α干扰素(IFN-α)治疗。11例接受6个月的病毒唑治疗。根据血清ALT的变化判断疗效。在治疗期间血清ALT降至正常且稳定者被认为初步有效;在终止治疗后血清ALT至少保持6个月正常者被
Changes in intrahepatic hepatitis C virus (HCV) antigen expression during antiviral therapy have not been validated. The authors evaluated the presence and significance of hepatic HCV antigen expression in patients with chronic hepatitis C before and after antiviral therapy. This study collected 49 liver biopsies from 35 patients who participated in antiviral treatment trials from 1987 to 1991. Twenty-four patients received interferon alpha (IFN-α) for 6 or 12 months. Eleven patients received ribavirin for 6 months. According to the change of serum ALT to determine the efficacy. Serum ALT was normal and stable during treatment was considered initially effective; serum ALT remained at least 6 months after termination of treatment