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目的:探讨高渗葡萄糖溶液治疗流行性出血热(EHF)的疗效。方法:用高渗葡萄糖溶液治疗EHF232例,并以平衡盐液治疗EHF230例作对照。结果:高渗葡萄糖溶液组患者的水肿、低血压休克的持续时间均短于平衡盐液组[(6±2对7±2)d,(17±5对21±6)h],氮质血症轻于平衡业液组[血尿素氨(27±9)mmol/L对(29±10)mmol/L,肌酐(587±104)μmol/L对(600±98)μmol/L];并发症的发生率和病死率也低于平衡盐液组(分别为26.7%对55.7%,9.5%对15.7%)。结论:以高渗葡萄糖溶液治疗EHF优于平衡盐液。
Objective: To investigate the efficacy of hypertonic glucose solution in the treatment of epidemic hemorrhagic fever (EHF). Methods: EHF was treated with hypertonic glucose solution in 232 cases, and balanced salt solution was used to treat EHF230 as control. Results: The duration of edema and hypotensive shock in hypertonic glucose solution group was shorter than that in balanced saline group [(6 ± 2 vs 7 ± 2) d, (17 ± 5 vs. 21 ± 6) h], nitrogen Serum levels were lower in the placebo group than in the placebo group (29 ± 10 mmol / L vs 58 ± 104 mmol / L vs 600 ± 98 μmol / L vs 27 ± 9 mmol / L for ammonia) Complications and mortality were also lower in the balanced salt group (26.7% vs. 55.7%, 9.5% vs. 15.7%, respectively). Conclusion: Hypertonic glucose solution is superior to balanced salt solution in treating EHF.