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应用Ｐ—选择素单克隆抗体免疫组化ＬＳＡＢ法，对６０例胃癌患者检测Ｐ—选择素在胃癌组织中的表达，并研究其表达与胃癌组织学分型、分化程度、淋巴转移、ＴＮＭ分期关系。结果发现６０例胃癌组织中３２例阳性，阳性率５３．３％。淋巴结癌转移者Ｐ—选择素阳性表达率为７０．３％，显著高于无淋巴转移的２６．１％（Ｐ＜０．０１）；晚期胃癌（Ⅲ、Ⅳ期）Ｐ—选择素阳性表达率为８０％，显著高于Ⅰ、Ⅱ期早期胃癌的表达率２６．７％，差别非常显著（Ｐ＜０．０１）。提示Ｐ—选择素表达与胃癌浸润深度、淋巴转移、ＴＮＭ分期密切相关。
The P-selectin monoclonal antibody immunohistochemistry LSAB method was used to detect the expression of P-selectin in gastric cancer tissues in 60 patients with gastric cancer. The relationship between the expression of P-selectin and the histological type, differentiation, lymphatic metastasis and TNM staging of gastric cancer was studied. . The results showed that 32 out of 60 cases of gastric cancer were positive and the positive rate was 53.3%. The positive expression rate of P-selectin in lymph node metastasis was 70.3%, which was significantly higher than that in non-lymphatic metastasis (26.1%) (P<0.01); positive expression of P-selectin in advanced gastric cancer (stages III and IV). The rate was 80%, which was significantly higher than that of 26.7% in stage I and stage II early gastric cancer. The difference was very significant (P<0.01). It is suggested that the expression of P-selectin is closely related to invasive depth, lymphatic metastasis and TNM staging of gastric cancer.