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目的 探讨柠檬酸提取物抗体 (CAE- Ab)及烟碱型乙酰胆碱受体抗体 (n Ach R- Ab)测定对临床早期诊断伴发胸腺瘤的重症肌无力 (MG)患者的价值 ,与改良 Osserm an分型及病理分型的关系。方法 采用酶联免疫吸附法检测 2 0例伴发胸腺瘤的重症肌无力患者的血清 CAE- Ab、n Ach R- Ab。结果 CAE- Ab阳性率 75 % ,n Ach R- Ab阳性率 6 0 % ,大多在 a型与 b型患者。上皮细胞为主型 4例中 b型 3例、CAE- Ab均阳性 ,术后发生肌无力危象 2例 ,1例死亡。结论 CAE- Ab及 n Ach R- Ab检测可作为临床诊断 MG患者伴发胸腺瘤的筛选检查 ;术后病理分型可指导治疗和判断预后。
Objective To investigate the value of determination of CAE-Ab and nAch R-Ab in early clinical diagnosis of myasthenia gravis associated with thymoma in patients with MG, an classification and pathological classification of the relationship. Methods Serum CAE-Ab and nAch R-Ab in 20 myasthenia gravis patients with thymoma were detected by enzyme-linked immunosorbent assay. Results The positive rate of CAE-Ab was 75% and the positive rate of nAch R-Ab was 60%, mostly in a type and b type. Epithelial cells in 4 cases of type b in 3 cases, CAE-Ab were positive, postoperative myasthenic crisis occurred in 2 cases, 1 case died. Conclusion The detection of CAE-Ab and nAch R-Ab can be used as a screening test for clinical diagnosis of MG patients with thymoma. Postoperative pathological classification can guide the treatment and prognosis.