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目的 探讨可溶性白细胞介素 2受体 (s IL- 2 R)和可溶性白细胞介素 6受体 (s IL- 6 R)在急性Guillain- Barre综合征 (GBS)发病中的作用。方法 采用 EL ISA方法测定 32例 GBS患者和 30名正常对照者血清 s IL- 2 R及 s IL- 6 R水平。结果 GBS患者血清 s IL- 2 R和 s IL- 6 R水平明显高于正常对照组 (P<0 .0 1,P<0 .0 5 ) ,重型和极重型患者明显高于轻型及中型患者 (P<0 .0 1,P<0 .0 5 ) ,且随着病情的好转 ,两种受体水平也逐渐下降 ,与治疗前比明显下降 (均 P<0 .0 5 )。结论 s IL- 2 R和 s IL- 6 R水平的高低可作为判断 GBS病情变化的指标之一。
Objective To investigate the role of soluble interleukin 2 receptor (sIL-2R) and soluble interleukin 6 receptor (sIL-6R) in the pathogenesis of acute Guillain-Barre syndrome (GBS). Methods Serum levels of IL-2R and s IL-6R in 32 GBS patients and 30 normal controls were measured by ELISA. Results Serum levels of sIL-2R and sIL-6R in patients with GBS were significantly higher than those in controls (P <0.01, P <0.05), and were significantly higher in patients with severe and very severe type than those with mild and moderate type (P <0.01, P <0.05). With the improvement of the disease, the levels of the two receptors also decreased gradually, compared with those before treatment (all P <0.05). Conclusion The levels of sIL-2R and sIL-6R can be used as one of the indicators to judge the severity of GBS.