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目的探讨妊娠前血尿酸水平与妊娠期高血压疾病(HDCP)的关系。方法采用前瞻性队列研究方法,以参加2006-2012年开滦职工健康体检并住院分娩的育龄妇女为观察队列(n=467),按中位数分为低尿酸组和高尿酸组。分析血尿酸与HDCP和子痫前期的关系。结果低尿酸和高尿酸组中HDCP和子痫前期的发病率分别为7.3%、3.0%和7.3%、3.9%(P>0.05)。多元线性回归结果显示基线尿酸值与孕晚期收缩压无关。多因素Logistic回归分析显示尿酸不是HDCP的影响因素(P>0.05)。影响HDCP发病的危险因素包括:高龄分娩(OR1.13,95%CI1.01~1.27,P<0.05)、基线高低密度脂蛋白胆固醇水平(OR1.97,95%CI 1.10~3.52,P<0.05)和高血压家族史(OR4.41,95%CI2.01~9.68,P<0.01)。结论妊娠前高尿酸血症与HDCP无关。
Objective To investigate the relationship between serum uric acid level and gestational hypertension (HDCP) before pregnancy. Methods A prospective cohort study was conducted to select women of childbearing age who were admitted to Kailuan for physical examination and hospital delivery from 2006 to 2012 as the observation cohort (n = 467). The median was divided into low uric acid group and high uric acid group. Analysis of the relationship between serum uric acid and HDCP and preeclampsia. Results The incidences of HDCP and preeclampsia in low uric acid and high uric acid groups were 7.3%, 3.0% and 7.3%, 3.9%, respectively (P> 0.05). Multivariate linear regression results showed no correlation between baseline uric acid levels and third trimester systolic blood pressure. Multivariate logistic regression analysis showed that uric acid was not the influencing factor of HDCP (P> 0.05). The risk factors influencing HDCP incidence were: older delivery (OR1.13, 95% CI1.01 ~ 1.27, P <0.05), baseline high and low density lipoprotein cholesterol levels (OR1.97, 95% CI 1.10-3.52, P < 0.05) and family history of hypertension (OR4.41,95% CI2.01 ~ 9.68, P <0.01). Conclusion Pre-pregnancy hyperuricemia has nothing to do with HDCP.