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把双链小分子RNA植入线虫等动物的细胞内,能够扰乱其中的同源信使RNA,使细胞不能制造特定的蛋白质,这种方法称为“RNA干扰”(RNAi)。这种现象也存在于哺乳类动物身上。因此,对哺乳类动物实施小分子RNA干扰也能取得相同的效果。
Implantation of double-stranded small molecule RNAs into the cells of animals such as nematodes can disturb the cognate messenger RNAs in them and prevent the cells from producing specific proteins. This is called “RNA interference” (RNAi). This phenomenon also exists in mammals. Therefore, small mammalian RNA interference can achieve the same effect.