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用不开颅的方法将血管内凝集剂从Ｗｉｓｔａｒ鼠颈内动脉注入，制成左大脑中动脉供血区局灶性脑缺血模型。并对鼠的血压、心电、体温、呼吸、脑电、血氧饱和度和血糖进行了监测，记录了这一模型的神经功能缺失程度，梗塞灶的体积和病理变化，实验结果表明局灶性脑缺血鼠的神经功能缺失评分多为２或３级，其梗塞灶主要位于第一感觉运动区，第二感觉运动区，外侧中央前区，内侧中央前区和基底节区，病理上表现为典型的缺血性改变。这一模型的建立为研究局灶性脑缺血的机理和治疗提供了一个简单的、可信的、不需开颅的新的动物模型。
Intravascular coagulants were injected intracranially into the Wistar rat intracranial artery without craniotomy to create a focal cerebral ischemia model of the left middle cerebral artery. The blood pressure, electrocardiogram, body temperature, respiration, electroencephalogram, blood oxygen saturation and blood glucose of the rats were monitored. The degree of neurological deficit, the volume and pathological changes of the infarct were recorded. The experimental results showed that the focal Most of the neurological deficits in STZ were grade 2 or 3, and infarction was mainly located in the first sensory area, the second sensory area, the lateral central anterior area, the medial central anterior area and the basal ganglia, The typical ischemic changes. The establishment of this model provides a simple and reliable new animal model for studying the mechanism and treatment of focal cerebral ischemia without craniotomy.