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目的:通过肺肠同治方药对柳氮磺胺吡啶(SASP)在溃疡性结肠炎(UC)灌肠治疗中的增效解毒作用揭示,证明该治法理论的科学性。方法:60例中医诊断为热毒炽盛证,西医诊断为UC的患者随机分为3组:对照组、治肠组、肺肠同治组,每组各20例,分别采单纯SASP灌肠(对照组),白头翁汤、调胃承气汤配合SASP灌肠(治肠组),白头翁汤、凉膈散配合SASP灌肠(肺肠同治组),持续60 d,各组治疗前后分别进行肠镜检查以作出临床疗效评价,并对患者血红蛋白(Hb),肝功能进行检测。结果:各组临床疗效评价:肺肠同治组>治肠组>对照组,差异有统计学意义(P<0.05);就Hb及肝功能而言:各组治疗前后比较,Hb皆有降低,ALT、AST皆有升高,差异有统计学意义(其中对照组、治肠组P<0.01,肺肠同治组P<0.05);各组治疗后比较,Hb为肺肠同治组>治肠组>对照组,ALT、AST为对照组>治肠组>肺肠同治组,差异有统计学意义(P<0.05)。结论:肺肠同治理论不仅对中医药与SASP协同灌肠治UC的增效研究具有指导意义,同样适用于其解毒效应研究。
OBJECTIVE: To demonstrate the synergistic detoxification effect of SASP in the treatment of ulcerative colitis (UC) enema by means of the method of the treatment of the method of the method of the method of the method of the method for treating lung and intestine Tongji. Methods: Sixty Chinese patients diagnosed with heat-toxin-flaming syndrome were randomly divided into three groups: control group, treatment group and treatment group. All patients in each group were treated with SASP enema (control group ), Pulsatilla Decoction, Tiaocheng Chengqi Decoction with SASP enema (treatment group), Pulsatilla Decoction, and Liangge San with SASP enema (lung intestine Tongzhi group) for 60 days. Before and after each treatment, colonoscopy was performed to make Clinical efficacy evaluation, and patients with hemoglobin (Hb), liver function testing. Results: The clinical efficacy evaluation of each group: the intestines of lung and intestine> the group of intestine and intestine> the control group, the difference was statistically significant (P <0.05). For Hb and liver function, Hb was decreased before and after treatment, ALT, AST were increased, the difference was statistically significant (control group, governance intestine group P <0.01, lung intestine Tongzhi group P <0.05); after treatment, Hb for lung intestine Tongzhi group> governance group > The control group, ALT, AST for the control group> governance intestine> lung intestine, the difference was statistically significant (P <0.05). Conclusion: The theory of intestine and intestine administration not only has the guiding significance for the synergistic research of UC with synergistic enema of TCM and SASP, but also applies to its detoxification effect.