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很多中药活性成分在体外具有确切的药效,但是由于自身的各种缺陷导致药物在体内有很小甚至没有药效,限制了在临床上的应用。中药活性成分与磷脂在非质子溶剂中形成磷脂复合物后,显示出与原料药不同的理化性质,尤其是由于药物磷脂复合物透膜能力的改善,使活性成分很容易进入体循环,其生物利用度得到很大的提高。因此,近几年来药物磷脂复合物受到了越来越多的关注。本文根据文献报道,分别从磷脂复合物的制备、表征、鉴定以及在药学方面的应用进行了综述。
Many traditional Chinese medicine active ingredients have the exact efficacy in vitro, but because of their various defects lead to drugs in the body with little or no efficacy, limiting the clinical application. After the active ingredients of Chinese traditional medicine and phospholipids form phospholipid complexes in aprotic solvents, they show different physical and chemical properties compared with that of bulk drugs. In particular, the active ingredients can easily enter the systemic circulation due to the improvement of the membrane permeability of the drug phospholipid complex, Degree has been greatly improved. Therefore, in recent years, drug phospholipid complex has received more and more attention. According to reports in the literature, the preparation, characterization and identification of phospholipid complexes and the application in pharmacy are reviewed respectively.