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目的了解广东省18岁及以上人群血脂异常患病率及其危险因素,为制定相应干预策略提供科学依据。方法采用多阶段分层随机整群抽样方法于2010年抽取广东省6个监测县(区、市)18岁及以上居民进行问卷调查(人口统计学资料、吸烟、喝酒、饮食和体力活动等)、体格检查(体重、身高和血压的测量)及血生化检测(甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、总胆固醇和血糖的检测),采用单因素、多因素非条件logistic回归分析血脂异常的危险因素。结果共调查3 577人,其中男性1 615人,平均年龄(50.28±14.05)岁,女性1 962人,平均年龄(49.21±13.51)岁。广东省18岁及以上人群血脂异常总患病率为60.7%(2 173/3 577),标化率为56.0%。男女性患病率分别为68.9%(1 113/1 615)和54.0%(1 060/1 962),男性高于女性(P<0.01)。城市和农村居民患病率分别为61.0%(1 088/1 785)和60.5%(1 085/1 792),城乡差异无统计学意义(P>0.05)。其中高胆固醇血症患病率为2.5%(标化率4.1%),混合型高脂血症患病率为1.9%(标化率3.3%),高甘油三酯血症患病率为4.5%(标化率5.0%),低高密度脂蛋白胆固醇血症患病率为57.3%(标化率49.9%)。多因素非条件logistic回归分析结果表明,超重(OR=1.554)、肥胖(OR=2.321)、腹部肥胖(OR=1.300)、吸烟(轻度、中度和重度吸烟OR值分别为2.189、2.042和1.874)和蔬菜摄入量<300 g/d(OR=1.389)是影响广东省18岁及以上人群血脂异常的危险因素,体质偏轻(OR=0.539)、身体活动活跃(OR=0.601)和身体活动充分(OR=O.658)是广东省18岁及以上人群血脂异常的保护因素。结论广东省18岁及以上人群血脂异常患病率已经达到较高水平,血脂异常以低高密度脂蛋白胆固醇血症和高甘油三酯血症为主,建议加强血脂异常的综合防治力度。
Objective To understand the prevalence and risk factors of dyslipidemia in Guangdong population aged 18 years and above, and to provide a scientific basis for formulating corresponding intervention strategies. Methods A multistage stratified random cluster sampling method was used to conduct questionnaire survey (demographic data, smoking, drinking, diet and physical activity, etc.) on residents aged 18 years and over in six monitoring counties (districts and cities) in Guangdong Province in 2010. , Physical examination (measurement of body weight, height and blood pressure) and blood biochemical tests (triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, total cholesterol and blood glucose test), univariate and multivariate non-conditional logistic Regression analysis of risk factors for dyslipidemia. Results A total of 3,577 men were surveyed, including 1,615 males, with an average age of 50.28 ± 14.05 years and 1 962 females, with an average age of 49.21 ± 13.51 years. The total prevalence of dyslipidemia in Guangdong population aged 18 years and over was 60.7% (2 173/3 577) with the standardization rate of 56.0%. The prevalence rates of males and females were 68.9% (1 113/1 615) and 54.0% (1060/1 962), respectively, higher in males than in females (P <0.01). The prevalence rates of urban residents and rural residents were 61.0% (1 088/1 785) and 60.5% (1 085/1 792) respectively, with no significant difference between urban and rural areas (P> 0.05). The prevalence of hypercholesterolemia was 2.5% (standardized rate of 4.1%), the prevalence of mixed hyperlipidemia was 1.9% (standardized rate of 3.3%), the prevalence of hypertriglyceridemia was 4.5 % (Standardized rate of 5.0%), the prevalence of low-density lipoprotein cholesterol is 57.3% (standardization rate of 49.9%). Multivariate non-conditional logistic regression analysis showed that overweight (OR = 1.554), obesity (OR = 2.321), abdominal obesity (OR = 1.300) and smoking (mild, moderate and severe smoking OR = 2.189, 2.042 and 1.874) and vegetable intake <300 g / d (OR = 1.389) were the risk factors of dyslipidemia in Guangdong population aged 18 years and above, with mild physical activity (OR = 0.539) Physical activity (OR = O.658) was a protective factor of dyslipidemia in Guangdong population aged 18 years and over. Conclusions The prevalence of dyslipidemia in Guangdong population aged 18 years and above has reached a high level. The main dyslipidemia is low-density lipoprotein cholesterol and hypertriglyceridemia. It is suggested to strengthen the comprehensive prevention and treatment of dyslipidemia.