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目的:探讨妊娠肝内胆汁淤积症 (ICP)患者外周静脉血清、新生儿脐静脉血清中一氧化氮 (NO)、内皮素 (ET)、丙二醛 (MDA)和超氧化物歧化酶 (SOD)含量的变化及在 ICP发病中的作用。方法:以 ICP组 2 8例为研究组 ,测定其外周静脉血清及新生儿脐静脉血清中的 NO、ET、MDA和 SOD,以年龄相近的 2 4例正常孕妇作为对照组。 结果 :ICP患者的 MDA和 ET含量较正常晚期妊娠显著增高 (P <0 .0 1) ,ICP患者的 NO和 SOD含量与对照组相比无显著性差异 (P >0 .0 5 )。母血清中 NO、ET、MDA含量均较新生儿脐静脉血清中的含量高 ,差异有显著性 (P <0 .0 1)。 结论 :妊娠期体内氧化和抗氧化失衡及 ET水平的增高可能与 ICP的发生、发展有关
Objective: To investigate the changes of peripheral blood serum, neonatal umbilical vein blood serum (NO), endothelin (ET), malondialdehyde (MDA) and superoxide dismutase (SOD) in patients with intrahepatic cholestasis of pregnancy ) Content changes and the role in the pathogenesis of ICP. Methods: Twenty-eight cases of ICP group were included in this study. The levels of NO, ET, MDA and SOD in peripheral venous blood and neonatal umbilical vein were determined. 24 normal pregnant women with similar age were used as control group. Results: The levels of MDA and ET in ICP patients were significantly higher than those in normal late pregnant women (P <0.01). There was no significant difference in NO and SOD levels between ICP patients and controls (P> 0.05). The contents of NO, ET and MDA in serum of maternal serum were higher than that of umbilical vein of newborn, the difference was significant (P <0.01). Conclusion: The imbalance of oxidation and antioxidation and the increase of ET level in pregnancy may be related to the occurrence and development of ICP