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目的对北京市东高地社区居民2年内高尿酸血症的发病情况进行分析,探讨高尿酸血症的危险因素。方法以参加2008年健康体检具有年龄、性别、BMI、血压、血脂、血糖、尿酸等资料且无高尿酸血症的北京某社区居民共3 261名作为观察对象,随访2年,2010年进行健康体检收集其基线相关资料,有效人数2 962名。计数资料采用χ2检验,危险因素分析用多因素Logistic回归,P<0.05为差异有统计学意义。结果检出高尿酸血症95例,发病率为3.2%。其中男发病率4.2%,女2.0%,男女比较差异有统计学意义(χ2=12.186,P<0.05)。男性高尿酸血症血症发病率各年龄组比较差异无统计学意义(P>0.05),女性高尿酸血症发病率存在年龄增长趋势(0、1.7%、2.9%、2.0%),各年龄组比较差异有统计学意义(P<0.05)。无论男女高尿酸血症的发病率均随着BMI的增加呈增高趋势。另外,男性肥胖人群发病率高于女性(P<0.05)。一直暴露于超重的人群发病率(5.4%)最高,而一直不超重的人群发病率(1.6%)最低,前者是后者的3.480倍(2.154~5.624),而且男性由无超重变为超重后发病率最高(8.6%),其发病风险是保持不超重男性的4.388倍(1.645~11.699),体重增加后男女高尿酸血症发生率存在差异。观察终点男性及女性均显示高血脂人群发病率高于血脂正常人群。结合基线高血脂的暴露水平,血脂增高者发病率(5.0%)最高,而一直血脂不高者发病率最低(2.4%),前者是后者的2.078倍(1.125~3.836)。基线高血压人群的发病率(4.7%)高于基线无高血压人群的发病率(2.4%)(P<0.05),前者是后者的2.006(1.331~3.022)倍。但这种差别主要表现在老年组人群中,老年高血压人群的发病率(4.9%)是非高血压人群发病率(2.8%)的1.810(1.115~2.940)倍。高尿酸血症危险因素为终点超重、男性、终点高血脂、基线高血压。结论积极控制中青年男性体重、血脂以及老年人群的血压是预防高尿酸血症的有效方法。
Objective To analyze the incidence of hyperuricemia in community residents of East Highland in Beijing in two years and explore the risk factors of hyperuricemia. Methods A total of 3 261 residents of a certain community in Beijing who participated in the 2008 2008 physical examination with age, sex, BMI, blood pressure, blood lipids, blood glucose, uric acid and other data and without hyperuricemia were followed up for 2 years and 2010 for health Physical examination collected their baseline information, effective number 2 962. Counting data using χ2 test, risk factors analysis using multivariate Logistic regression, P <0.05 for the difference was statistically significant. Results of detection of hyperuricemia in 95 cases, the incidence was 3.2%. Including male incidence 4.2%, 2.0% female, male and female difference was statistically significant (χ2 = 12.186, P <0.05). There was no significant difference in the incidence of hyperuricemia among all age groups (P> 0.05). The prevalence of hyperuricemia in women increased with age (0,1.7%, 2.9%, 2.0%), The difference was statistically significant (P <0.05). Both the incidence of male and female hyperuricemia increased with the increase of BMI. In addition, the incidence of obesity in males was higher than that in females (P <0.05). The highest incidence was found in those who had been exposed to overweight (5.4%) and the lowest (1.6%) in those who were never overweight. The former was 3.480 times (2.154-5.624) of the latter, and the number of overweight The incidence was highest (8.6%). The risk of the disease was 4.388 times (1.645 ~ 11.699) than that of the non-overweight males. There was a difference in the incidence of hyperuricemia between men and women after weight gain. Both men and women at the end of the study showed that the incidence of hyperlipidemia was higher in patients with normal blood lipids. Combined with baseline hyperlipidemia, the incidence of hyperlipidemia was the highest (5.0%) and lowest (2.4%), the former 2.078 times (1.125-3.836). The incidence of baseline hypertension (4.7%) was higher than that of the baseline non-hypertensive population (2.4%) (P <0.05), with the former being 2.006 (1.331-3.022) times the latter. However, this difference is mainly manifested in that the incidence of elderly hypertensive population (4.9%) is 1.810 (1.115 ~ 2.940) times higher than that of non-hypertensive population (2.8%) in the elderly population. Hyperuricemia risk factors for overweight, male, end point hyperlipidemia, baseline hypertension. Conclusion It is an effective way to prevent hyperuricemia by actively controlling body weight, blood lipid and blood pressure of the middle-aged and young men.