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目的:探讨便可通对阴虚血瘀型功能性便秘小鼠肠动力影响的机制。方法:观察便可通对正常和阴虚血瘀型功能性便秘小鼠的排粪、碳末推进率和血清超氧化物歧化酶(SOD)的影响。结果:正常小鼠第6天和阴虚血瘀型功能性便秘小鼠在第7天,便可通中剂量组较麻仁胶囊、新斯的明、蒸馏水组粪便排出粒数多(P<0.05),且粪便稀软,不成形;碳末推进率优于麻仁胶囊、新斯的明、蒸馏水组(P<0.05);血清SOD活性明显高于麻仁胶囊、新斯的明、蒸馏水组(P<0.05)。结论:便可通是治疗阴虚血瘀型功能性便秘的有效制剂。
OBJECTIVE: To investigate the mechanism of effect of Yitongtong on intestinal motility in mice with functional constipation due to yin deficiency and blood stasis. Methods: Observe the effects of defecation, carbon-assisted advancing rate, and serum superoxide dismutase (SOD) on functional constipation in mice with normal and yin deficiency and blood stasis. RESULTS: On the 6th day of normal mice and mice with functional constipation due to yin deficiency and blood stasis type, on the 7th day, the amount of feces in the feces in the Tongke capsule group, neostigmine, and distilled water group was higher in the Tongkezhongdose group (P< 0.05), and feces is soft and unshaped; the rate of carbon at the end of the promotion is better than that of Mareng Capsules, Neostigmine, and distilled water group (P<0.05); Serum SOD activity is significantly higher than that of Mareng Capsules, Neostigmine, Distilled water Group (P < 0.05). Conclusion: Yitongtong is an effective preparation for the treatment of functional constipation due to yin deficiency and blood stasis.