脓毒症是指由局部或全身感染引起的全身性炎性反应综合征。近年来,脓毒症的发病率呈日趋增高的趋势,且其病死率仍居高不下。导致脓毒症死亡的原因很多,其中心功能的障碍是重要原因之一。目前对脓毒症导致心功能障碍的机制尚无确切定论,涉及细菌毒素、细胞因子、氧自由基、补体系统、自主神经系统、线粒体损伤导致能量代谢障碍等多方面。其中,心肌能量代谢的障碍在心功能障碍过程中发挥着重要作用。 Sepsis refers to systemic inflammatory response syndrome caused by local or systemic infection. In recent years, the incidence of sepsis is an increasing trend, and its mortality remains high. Cause of sepsis caused by many causes of death, the central dysfunction is one of the important reasons. At present, the mechanism of sepsis-induced cardiac dysfunction has not been conclusive, and many aspects are involved such as bacterial toxins, cytokines, oxygen free radicals, complement system, autonomic nervous system, and mitochondrial damage caused by energy metabolism. Among them, the obstacle of myocardial energy metabolism plays an important role in the process of cardiac dysfunction.