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目的:通过研究不同负荷有氧运动对大鼠动脉粥样硬化发生发展过程中血浆及心肌AngII含量的影响,为动脉粥样硬化运动处方的制定提供一定的理论参考。方法:雄性Wistar大鼠40只,随机分为正常对照组(NC);动脉粥样硬化组(AS);动脉粥样硬化+60min有氧运动组(ASAT1);动脉粥样硬化+120min有氧运动组(ASAT2)。放免法测定血浆及心肌组织AngII。结果:AS组与NC组相比,血浆AngII显著升高(P<0.05);心肌AngII显著升高(P<0.05)。ASAT1、ASAT2两组与AS组相比,血浆AngII显著下降(P<0.05);ASAT1组心肌AngII显著低于AS组(P<0.05)。ASAT2与ASAT1相比心肌AngII显著升高。结论:60min有氧训练可以使大鼠动脉粥样硬化发生发展过程中血浆和心肌组织AngII降低,延缓动脉粥样硬化的进程;120min有氧训练与60min有氧训练相比,使该过程中大鼠血浆和心肌AngII升高。从一定程度上说明较长时间的有氧运动并不能进一步改善动脉粥样硬化。
OBJECTIVE: To study the effects of different aerobic exercises on plasma and myocardial Ang II levels during the development of atherosclerosis in rats, and to provide some theoretical references for the formulation of exercise prescription for atherosclerosis. Methods: Forty male Wistar rats were randomly divided into normal control group (NC), atherosclerosis group (AS), atherosclerosis + 60 min aerobic exercise group (ASAT1), atherosclerosis + 120 min aerobic Exercise group (ASAT2). The radioimmunoassay was used to measure AngII in plasma and myocardium. Results: Compared with NC group, plasma AngII was significantly increased in AS group (P <0.05), while AngII in myocardium was significantly increased (P <0.05). The level of Angll in ASAT1 and ASAT2 groups was significantly lower than that in AS group (P <0.05). The level of AngII in ASAT1 group was significantly lower than that in AS group (P <0.05). Compared with ASAT1, ASAT2 significantly increased myocardial AngII. CONCLUSION: Aerobic training at 60min can reduce AngII in plasma and myocardial tissue during the development of atherosclerosis in rats and delay the process of atherosclerosis. Compared with 60min aerobic training, aerobic training at 120min Rat plasma and myocardial AngII increased. To some extent, it shows that a longer period of aerobic exercise does not further improve atherosclerosis.