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目的探究解毒通络汤联合替诺福韦酯辅助治疗对乙型肝炎患者血清IL-18、IL-12、IL-37及TNF-α水平影响。方法收集我科乙型肝炎患者33例,根据治疗方法不同分为对照组和治疗组,其中治疗组17例,对照组16例,均采用临床乙型肝炎常规治疗方案,治疗组在此基础上解毒通络汤辅助治疗,治疗结束后对比分析血清IL-18、IL-12、IL-37、TNF-α水平以及不良反应。结果治疗后与对照组相比,治疗组患者的IL-18、IL-12水平较低,差异具有统计学意义(P<0.05);治疗组患者IL-37水平较低,TNF-α水平较低,差异具有统计学意义(P<0.05);治疗组患者的不良反应发生率较低,差异具有统计学意义(P<0.05)。结论解毒通络汤联合替诺福韦酯辅助治疗乙型肝炎具有抑制病毒复制,抗病毒,改善肝功能以及免疫反应机制。
Objective To explore the effects of Jiedu Tongluo Decoction combined with tenofovir disoproxil on serum IL-18, IL-12, IL-37 and TNF-α in patients with hepatitis B infection. Methods Thirty-three patients with hepatitis B were collected in our department. According to the different treatment methods, they were divided into control group and treatment group, 17 cases in the treatment group and 16 cases in the control group. All the patients were treated with routine hepatitis B treatment. Jiedu Tongluo Tang adjuvant therapy, comparative analysis after treatment serum IL-18, IL-12, IL-37, TNF-α levels and adverse reactions. Results Compared with the control group, the levels of IL-18 and IL-12 in the treatment group were lower after treatment (P <0.05), while the levels of IL-37 and TNF-α in the treatment group were lower than those in the control group The difference was statistically significant (P <0.05). The incidence of adverse reactions in the treatment group was lower, the difference was statistically significant (P <0.05). Conclusion Jiedu Tongluo Decoction combined with tenofovir dipivoxil-assisted treatment of hepatitis B can inhibit viral replication, anti-virus, improve liver function and immune response mechanism.