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目的评价普瑞巴林与曲马多联合治疗中重度急性带状疱疹疼痛的临床效果。方法中重度急性带状疱疹患者72例,随机分为曲马多组、普瑞巴林组和联合组,比较三组治疗效果。结果治疗4周后,三组患者数字疼痛分级法(NRS)、匹兹堡睡眠质量指数量表(PSQI)评分均较治疗前有明显下降,联合组NRS、PSQI评分均明显低于曲马多组和普瑞巴林组(P<0.05);三组不良反应发生发生率比较差异无统计学意义(P>0.05),联合组曲马多日最大剂量明显低于曲马多组(P<0.05)。结论普瑞巴林联合曲马多治疗中重度急性带状疱疹疼痛可有效改善患者疼痛,减少曲马多用药剂量,且具有一定的安全性,值得临床推广应用。
Objective To evaluate the clinical efficacy of combination of pregabalin and tramadol in the treatment of moderate-to-severe acute herpes zoster pain. Methods A total of 72 patients with severe acute shingles were randomly divided into tramadol group, pregabalin group and combination group. The therapeutic effects of the three groups were compared. Results After 4 weeks of treatment, the NRS scores and Pittsburgh Sleep Quality Index (PSQI) scores of the three groups were significantly lower than those before treatment. The scores of NRS and PSQI in the combination group were significantly lower than those in the tramadol group and the PSQI group Pregabalin group (P <0.05). There was no significant difference in the incidence of adverse reactions between the three groups (P> 0.05). The maximum dose of tramadol in the combination group was significantly lower than that of the tramadol group (P <0.05). Conclusion Pregabalin combined with tramadol in the treatment of moderate and severe acute herpes zoster pain can effectively improve the patient’s pain, reduce the dose of tramadol, and has a certain safety, worthy of clinical application.