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采用经精制得到的反式结构的4-(4-丙基环己基)环己醇(简称3HHE)为原料,与氢化钠反应生成相应的醇钠,再与碘甲烷反应,得到目标产物液晶单体(反,反),4-丙基-4’-甲氧基双环己烷(简称301HH),并对反应的影响因素进行了研究和探讨,得出了最佳反应条件。由于产品纯度要求(GC)不小于99.5%,水含量(GC)小于500mg/L,单项杂质含量(GC)不超过0.3%,故对产品进行精制。实验操作过程中采用一次性加料,操作简单,反应过程中无毒害气体放出,原料3HHE反应完全,是比较理想的合成路线。
The purified trans-4- (4-propylcyclohexyl) cyclohexanol (abbreviated as 3HHE) is used as a raw material to react with sodium hydride to obtain the corresponding sodium alcoholate, which is then reacted with methyl iodide to obtain the target product liquid crystal single (Anti, anti), 4-propyl-4’-methoxy bicyclohexane (referred to as 301HH), and the factors affecting the reaction were studied and discussed, the best reaction conditions were obtained. The product is refined due to the purity of the product (GC) of not less than 99.5%, the water content (GC) of less than 500 mg / L and the individual impurity content (GC) of not more than 0.3%. The experimental operation using a one-time feed, the operation is simple, non-toxic gas emissions during the reaction process, the raw material 3HHE reaction is complete, is an ideal synthetic route.