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目的 通过肛管直肠恶性黑色素瘤 2 9例临床分析 ,研究各种因素对生存期的影响。方法 通过 2 9例肛管直肠恶性黑色素瘤的 5年追踪 ,临床分析 ,比较年龄、性别、肿物浸润肠腔的范围 ,肿瘤大小 ,区域淋巴结有无转移及各种治疗方法对生存期的影响 ,探讨提高生存率、延长生存期的治疗手段。结果 肛管直肠恶性黑色素瘤无特殊的临床表现 ,极易误诊为直肠癌、直肠息肉和血栓性痣。诊断必须依据组织病理学。如能早期诊断 ,且行以经会阴直肠根治术为主 ,辅助化疗、免疫治疗 ,就能延长生存期 ,提高生存率。单纯化疗、放疗效果不理想。结论 加强对肛管直肠恶性黑色素瘤的认识 ,早期确诊 ,行Miles氏手术为主的综合治疗是延长此病生存期 ,提高生存率行之有效的方法。
Objective To investigate the effect of various factors on the survival of 29 patients with anorectal malignant melanoma. Methods A total of 29 patients with anorectal malignant melanoma were followed up for 5 years. The clinical data were analyzed. The effects of age, gender, tumor size, tumor size, regional lymph node metastasis and various treatment methods on survival were compared , To explore ways to improve the survival rate and extend the survival of the treatment. Results Anorectal malignant melanoma without special clinical manifestations, easily misdiagnosed as rectal cancer, polyps and thrombosis rectal nevus. Diagnosis must be based on histopathology. If early diagnosis, and line to the main perineal radical surgery, adjuvant chemotherapy, immunotherapy, can extend the survival and improve survival. Simple chemotherapy, radiotherapy results are not satisfactory. Conclusion To strengthen the understanding of anorectal malignant melanoma, early diagnosis, line Miles’s comprehensive treatment is to extend the survival of the disease, improve the survival rate of the effective method.