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危重患儿常发生高血糖症,这与不良结局有关。将血糖降至年龄校正的正常空腹血糖值能否改善不良结局尚不清楚。研究纳入700例危重患儿,317例婴儿(年龄<1岁)和383例儿童(年龄≥1岁),均在比利时Leuven大学医院的儿科重症监护室(PICU)接受治疗。患儿被随机分为强化胰岛素治疗组(PICU期间,婴儿目标血糖值2.8～4.4 mmol/L,儿童目标血糖值3.9～5.6 mmol/L;
Critically ill children often have hyperglycemia, which is associated with adverse outcomes. It is unclear whether lowering blood glucose to age-adjusted normal fasting blood glucose levels can improve adverse outcomes. The study included 700 critically ill children, 317 infants (aged <1 year) and 383 children (≥1 year-old) undergoing pediatric intensive care unit (PICU) at Leuven University Hospital in Belgium. Children were randomized to intensive insulin therapy (target PICU infants 2.8 to 4.4 mmol / L for blood glucose and 3.9 to 5.6 mmol / L for children)