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目的探讨血栓调节蛋白(TM)在乳腺癌组织中的表达。方法应用免疫组织化学法对94例乳腺癌、10例乳腺纤维腺瘤组织中的TM表达水平进行检测。结果TM在乳腺癌组织中的表达明显高于乳腺纤维腺瘤组织中的表达(P<0.01)。在乳腺癌组织中TM的表达与临床分期、淋巴结转移状况有关,随着临床分期的增高,其阳性表达率逐渐下降(P<0.05)。淋巴结阴性组阳性表达率为66.7%,淋巴结阳性组阳性表达率为44.2%(P<0.05)。TM与肿瘤组织病理学分级、病理学类型、肿瘤最大径无统计学意义(P>0.05)。结论TM表达水平可能与乳腺癌的发展、转移有关,有望成为判断乳腺癌患者病情发展和预后的一项新指标。
Objective To investigate the expression of thrombomodulin (TM) in breast cancer. Methods The expression of TM in 94 cases of breast cancer and 10 cases of breast fibroadenoma was detected by immunohistochemistry. Results The expression of TM in breast cancer was significantly higher than that in breast fibroadenoma (P <0.01). The expression of TM in breast cancer was correlated with clinical stage and lymph node metastasis. The positive expression rate of TM decreased gradually with the increase of clinical stage (P <0.05). The positive expression rate of lymph node negative group was 66.7%, and the positive expression rate of lymph node positive group was 44.2% (P <0.05). TM and tumor histopathological grade, pathological type, maximum diameter of tumor was not statistically significant (P> 0.05). Conclusion The expression level of TM may be related to the development and metastasis of breast cancer, which is expected to be a new indicator to judge the progression and prognosis of breast cancer patients.