雷尼替丁问世以来,提倡的所谓标准用法是150mg一日二次口服。但在86年4月东京召开的有关讨论会上,不少与会者报告了睡前一次投服300mg的投药方法,并以实际经验加以证实其有效性和合理性。竹本忠良氏引用Dragstedt的名言:“夜间当心,溃疡当心”(“night guard,ulcer guard”),提醒消化性溃疡主要在夜间形成。竹本氏赞成投药方法从150mg一日二次的标准用药法改为300mg每晚投用一次。该氏列举了Dammann1985年的资料,即睡前一次投药300mg,夜间胃酸分泌的抑制率达92％。盐饱德行氏以睡前一次投药法治疗胃溃疡21例,十二指肠溃疡10例,前者用药8周,后者用药6周,以内镜观察治愈率。结果胃溃 Since the advent of ranitidine, the so-called standard usage advocated is 150mg orally twice daily. However, during the symposium held in Tokyo in April 866, many participants reported a method of dosing 300mg once before going to bed, and confirmed its effectiveness and rationality based on actual experience. Toshimoto Takeshi quoted Dragstedt’s famous quote: “Night guard, ulcer guard”, reminding peptic ulcer mainly at night. Bamboo is favored by the administration method from 150mg twice a day standard medication to 300mg per night. The article lists the 1985 Dammann’s contribution, that is, a dose of 300mg before going to bed, night gastric acid secretion inhibition rate of 92%. Salt full line to bed before treatment once a drug treatment of gastric ulcer in 21 cases, 10 cases of duodenal ulcer, the former medication for 8 weeks, the latter for 6 weeks to observe the endoscopic cure rate. The results of gastric ulcer