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目的:探讨急性缺血性脑卒中患者血浆B型脑钠肽前体(NT-proBNP)和D-二聚体水平与病情严重程度的关系。方法:选取2013年6月-2015年6月在我院接受治疗的急性缺血性脑卒中患者81例作为研究对象,另选取同期在我院接受健康体检的志愿者53例作为对照组。检测并比较两组血浆NT-proBNP及D-二聚体水平。结果:急性脑卒中患者血浆NT-proBNP与D-二聚体水平均显著高于对照组,差异具有统计学意义(P<0.05)。大面积梗死的缺血性脑卒中患者血浆NT-proBNP及D-二聚体水平显著高于非大面积梗死患者,差异具有统计学意义(P<0.05);NIHSS评分>10的缺血性脑卒中患者血浆NT-proBNP及D-二聚体水平显著高于NIHSS评分≤10的患者,差异具有统计学意义(P<0.05);有意识障碍的缺血性脑卒中患者血浆NT-proBNP及D-二聚体水平显著高于无意识障碍者,差异具有统计学意义(P<0.05);随访结局为死亡的缺血性脑卒中患者血浆NT-proBNP及D-二聚体水平显著高于存活者,差异具有统计学意义(P<0.05)。结论:NT-proBNP及D-二聚体水平可以反映急性缺血性脑卒中患者的病情,对脑卒中患者的病情评估及预后判断具有参考价值。
Objective: To investigate the relationship between plasma B-type natriuretic peptide precursor (NT-proBNP) and D-dimer in patients with acute ischemic stroke and the severity of the disease. Methods: A total of 81 acute ischemic stroke patients treated in our hospital from June 2013 to June 2015 were selected as the research object. Another 53 volunteers who were in our hospital during the same period were selected as the control group. Plasma NT-proBNP and D-dimer levels were measured and compared in both groups. Results: The plasma levels of NT-proBNP and D-dimer in patients with acute stroke were significantly higher than those in the control group (P <0.05). The plasma levels of NT-proBNP and D-dimer were significantly higher in ischemic stroke patients with large infarcts than those in non-large infarcts (P <0.05). The ischemic brain with NIHSS score> 10 The plasma levels of NT-proBNP and D-dimer in stroke patients were significantly higher than those in patients with NIHSS score ≤10 (P <0.05). The levels of plasma NT-proBNP and D- Dimer level was significantly higher than that of unconscious people (P <0.05). The plasma levels of NT-proBNP and D-dimer were significantly higher in survivors with ischemic stroke at follow-up than survivors, The difference was statistically significant (P <0.05). Conclusion: The levels of NT-proBNP and D-dimer can reflect the condition of patients with acute ischemic stroke and have reference value for the assessment of stroke and the prognosis of patients with stroke.