Hexabromocyclododecanes (HBCDs) are the most common brominated flame-retardants after polybrominated diphenyl ethers.HBCDs can induce cancer by causing inappropriate antidiuretic hormone syndrome.Environmental contamination with HBCDs has been detected globally,with concentrations ranging from ng to μg.Methods to degrade HBCDs include physicochemical methods,bioremediation,and phytoremediation.The photodegradation of HBCDs using simulated sunlight or ultraviolet lamps,or chemical catalysts are inefficient and expensive,as is physicochemical degradation.Consequently,bioremediation is considered as the most cost-effective and clean approach.To date,five bacterial strains capable of degrading HBCDs have been isolated and identified:Pseudomonas sp.HB01,Bacillus sp.HBCD-sjtu,Achromobacter sp.HBCD-1,Achromobacter sp.HBCD-2,and Pseudomonas aeruginosa HS9.The molecular mechanisms of biodegradation of HBCDs are discussed in this review.New microbial resources should be explored to increase the resource library in order to identify more HBCD-degrading microbes and functional genes.Synthetic biology methods may be exploited to accelerate the biodegradation capability of existing bacteria,including modification of the degrading strains or functional enzymes,and artificial construction of the degradation microflora.The most potentially useful method is combining microdegradation with physicochemical methods and phytoremediation.For example,exogenous microorganisms might be used to stimulate the adsorption capability of plants for HBCDs,or to utilize an interaction between exogenous microorganisms and rhizosphere microorganisms to form a new rhizosphere microbial community to enhance the biodegradation and absorption of HBCDs.